PsychoTropicalResearch, serotonin and serotonin syndrome research.
Antidepressants - Receptor affinities(3)
Antidepressants - Receptor affinities(3)
Date Created: 21/06/1999 Last Modified: 19/01/2002 Last Checked: 04/09/2003
5-HT2A receptors
Studies using sleep EEGs on new drugs like nefazodone and mirtazapine suggest that 5-HT2A blockade produces an improvement in sleep patterns that is clinically useful. Many antidepressant drugs have such properties, data as below. Low numbers means high potency, ie bigger effect.
Many neuroleptic drugs, both old and new, are also potent 5-HT2A blockers.
SSRIs nil sig except
fluoxetine 280
Trimipramine 15
Amitriptyline 18
Clomipramine 23
Doxepin 27
Trazodone 25
Nefazodone 26
mirtazapine ~30
Nortriptyline 41
Imipramine 150
desipramine 350
lofepramine 200
All text ©Dr Ken Gillman MRC Psych - PsychoTropical Research®
|Return to the menu at the top of this page|