PsychoTropical Research - Dr Ken Gillman, Serotonin Syndrome, Mirtazapine, Dual Action Drugs. Cytochrome P450 enzymes - Answers to Quiz.

PsychoTropicalResearch, serotonin and serotonin syndrome research.

Cytochrome P450 enzymes - Answers to Quiz

Cytochrome P450 enzymes - Answers to Quiz

Questions 1 through 4. Which one of the combinations of commonly used drugs below has not been documented to cause, or been implicated in causing, serious or fatal interactions (as a result of CYP450 interactions)

1)
codeine and paroxetine
beta-blockers and fluoxetine
dothiepin and paroxetine

2)
erythromycin and ergotamine
ketoconazole and sildenafil
nefazodone and lorazepam

3)
'statins and nefazodone
carbamazepine and clarithromycin
clomipramine and moclobemide

4)
Phenytoin and fluvoxamine
tolbutamide and citalopram
warfarin and fluoxetine


5) Which one of the widely used 'OTC' health remedies below does not appear to significantly block any CYP450 enzyme sub-type:--
Hypericum perforatum (St. John's wort)
Matricaria chamomilla (chamomile)
High dose vitamin E
Hydrastis canadensis (goldenseal)


6) CYP450 2D6 is not significantly blocked by which one of the following
paroxetine
nefazodone
fluoxetine

7) CYP450 3A4 is not significantly blocked by which one of the following
ketoconazole
quinidine
fluoxetine

8) CYP450 2C9 is not significantly blocked by which one of the following
fluvoxamine
fluoxetine
mirtazapine