A quiz about CYP450

Below is a quiz indicating knowledge about cytochrome P450 enzyme (CYP450) drug-drug interactions.

Which one of these trios of combinations of drugs has not been documented as a likely cause of serious (causing admission to hospital) CYP450 mediated pharmacokinetic drug-drug interaction?

    • codeine and paroxetine
    • beta-blockers and fluoxetine
    • dothiepin and fluvoxamine
    • venlafaxine + bupropion
    • venlafaxine + nortriptyline
    • phenelzine + dothiepin
    • Phenytoin and imipramine
    • lansoprazole and fluvoxamine
    • warfarin and fluoxetine
    • moclobemide + nortriptyline
    • moclobemide + imipramine
    • moclobemide + phenytoin
    • erythromycin and ergotamine
    • ketoconazole and sildenafil
    • sodium valproate and lorazepam
    • fluvoxamine + imipramine
    • fluvoxamine + nortriptyline
    • fluvoxamine + caffeine
    • clozapine + fluoxetine
    • thioridazine + fluvoxamine
    • clozapine + mirtazapine
    • risperidone + benztropine
    • risperidone + citalopram
    • risperidone + sertraline
    • bupropion + tranylcypromine
    • bupropion + clozapine
    • bupropion + chlorpheniramine
    • fluoxetine + pimozide
    • fluoxetine + moclobemide
    • fluoxetine + reboxetine