A quiz about CYP450

Below is a quiz indicating knowledge about cytochrome P450 enzyme (CYP450) drug-drug interactions.

Which one of these trios of combinations of drugs has not been documented as a likely cause of serious (causing admission to hospital) CYP450 mediated pharmacokinetic drug-drug interaction?

1. • codeine and paroxetine
   • beta-blockers and fluoxetine
   • dothiepin and fluvoxamine
2. • venlafaxine + bupropion
   • venlafaxine + nortriptyline
   • phenelzine + dothiepin
3. • Phenytoin and imipramine
   • lansoprazole and fluvoxamine
   • warfarin and fluoxetine
4. • moclobemide + nortriptyline
   • moclobemide + imipramine
   • moclobemide + phenytoin
5. • erythromycin and ergotamine
   • ketoconazole and sildenafil
   • sodium valproate and lorazepam
6. • fluvoxamine + imipramine
   • fluvoxamine + nortriptyline
   • fluvoxamine + caffeine
7. • clozapine + fluoxetine
   • thioridazine + fluvoxamine
   • clozapine + mirtazapine
8. • risperidone + benztropine
   • risperidone + citalopram
   • risperidone + sertraline
9. • bupropion + tranylcypromine
   • bupropion + clozapine
   • bupropion + chlorpheniramine
10. • fluoxetine + pimozide
    • fluoxetine + moclobemide
    • fluoxetine + reboxetine